• In vivo data generated using

  2018-11-05

  

  In vivo data generated using hCD40Tg animals further demonstrate that antigen targeting to CD40 is an efficient way to evoke antigen-specific CD8+ T cell responses in vivo. Although we could not compare CD40 with LOX-1 or Dectin-1 in this animal model due to the limited specificities of mAbs (αLOX-1

• When untargeted analysis is considered pharmacometabolomics

  2018-11-05

  

  When untargeted analysis is considered, pharmacometabolomics also serves as a tool to shape hypothesis, as multiple analytes are quantified simultaneously and pharmacometabolomic modeling appears not to be limited by prior understanding or hypotheses. Hence, pharmacometabolomic modeling can be a pow

• The additive impact of progressive changes in sleep quality

  2018-11-05

  

  The additive impact of progressive changes in sleep quality and structure, changes in cerebral blood flow, neurovascular and neurotransmitters, plus the cellular redox status are all likely to contribute to the cognitive deficits reported in up to one out of four newly diagnosed OSA patients (Rosenz

• Interestingly dataset analyses show that HK is highly

  2018-11-05

  

  Interestingly, dataset analyses show that HK2 is highly expressed in CRPC compared to the primary prostate cancer. Our findings thus provide preclinical proof-of-concept that co-targeting Warburg effect with 2-DG and autophagy with CQ could be extended to effectively treat CRPC patients whose tumors

• Second when talking about risk

  2018-11-05

  

  Second, when talking about risk associated with alcohol consumption, it makes little sense to use words such as safe. Rather, risk needs to be examined for each disease outcome separately because pathways and risk differ from disease to disease, and the same amount of alcohol may be associated with

• TAPI-1 br Results br Discussion The sterol sensing orphan

  2018-11-05

  

  Results Discussion The sterol-sensing ‘orphan’ NR, RORα, is expressed in a number of metabolically active tissues and cell types, including the adipose tissue, muscle, resident tissue macrophages and lymphocytes (Bookout et al., 2006). This NR has been implicated in the regulation of lipid hom

• br Declaration of Interests br Author Contributions br Ackno

  2018-11-05

  

  Declaration of Interests Author Contributions Acknowledgments This work was supported by the EU FP7 project TBIcare (Project ref. 270259; to M.O., D.M., and O.T.), by the GE-NFL Head Health Challenge I Award (grant no. 7620 to M.O. and T.H.), by personal EVO funding (Finland) (to J.P.P and

• Although more GWAS on sepsis traits will be accomplished in

  2018-11-05

  

  Although more GWAS on sepsis traits will be accomplished in the coming years, it is worth noting that these studies allow analyzing a modest fraction of all existing variants in our genome. In , present their results from a study using a promising alternative taking advantage of high-throughput DNA

• The variable gender is the most studied resource of

  2018-11-05

  

  The variable ‘gender’ is the most studied resource of the voice in the literature on radio. Its advertising effectiveness has been studied, although with contradictory results (Wolin, 2003). With our study, we attempt to contribute by determining whether the prevalence of male spokespersons detected

• br Materials and methods br Results

  2018-11-05

  

  Materials and methods Results and discussion Concluding remarks The compositions and properties of three subtropical soils sampled from respective active disposal sites around the City of Johannesburg (CoJ) were studied together with the chemical alterations that occurred when percolated wi

• A chemically defined growth medium regularly

  2018-11-05

  

  A chemically-defined growth medium regularly used for growing P. pastoris was previously developed by Invitrogen Inc. (San Diego, CA, USA) and consists of basal salts, a Pichia trace metals (PTM1) solution specifically formulated for Pichia cultures and a carbon source (Invitrogen Corporation, 2002)

• Much work has been done previously in community

  2018-11-05

  

  Much work has been done previously in community-dwelling older adults on the relationship between the level of physical activity and sleeping. These studies have involved direct comparisons between physically fit and unfit groups [6,7], cross-sectional observational studies [8–11], and randomized co

• The International Classification of Sleep Disorders defined

  2018-11-05

  

  The International Classification of Sleep Disorders defined short sleep as ≤5h and long sleep as ≥9h [42]. However, the categories of self-rated SD used by NSF Poll 2013 [43] are different from those found in the current literature, which interfere with accurate comparisons. In Table 1, we depict di

• Altered thalamocortical dynamics are the basis for several

  2018-11-05

  

  Altered thalamocortical dynamics are the basis for several types of neurological and neuropsychiatric conditions named thalamocortical dysrhythmia syndrome[11,12]. Abnormal activity of relay neurons has been related to an increase of low frequency oscillatory activity due to protracted activation of

• br Conclusion br Conflicts of

  2018-11-05

  

  Conclusion Conflicts of interest Acknowledgments This work was aided by the Japan Society for the Promotion of Science (JSPS) through the Grant-in-Aid for JSPS Fellows. The authors thank Dr. Thomas Maloney for kind and detailed editing of the manuscript. Introduction Prevalence of obesi

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